The biology of the combretastatins as tumour vascular targeting agents
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چکیده
منابع مشابه
Combretastatins: more than just vascular targeting agents?
Several prodrugs of the naturally occurring combretastatins have undergone extensive clinical evaluation as vascular targeting agents (VTAs). Their increased selectivity toward endothelial cells together with their innate ability to rapidly induce vascular shutdown and inhibit tumor growth at doses up to 10-fold less than the maximum tolerated dose led to the clinical evaluation of combretastat...
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Vascular targeting agents (VTAs) for the treatment of cancer are designed to cause a rapid and selective shutdown of the blood vessels of tumors. Unlike antiangiogenic drugs that inhibit the formation of new vessels, VTAs occlude the pre-existing blood vessels of tumors to cause tumor cell death from ischemia and extensive hemorrhagic necrosis. Tumor selectivity is conferred by differences in t...
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ژورنال
عنوان ژورنال: International Journal of Experimental Pathology
سال: 2002
ISSN: 0959-9673
DOI: 10.1046/j.1365-2613.2002.00211.x